This episode discusses a series of longevity myths that Dr. Kaeberlein wants to debunk. The first myth is that it is possible to directly measure biological age. However, Matt explains that we currently have no tools that can truly measure biological age - tools like epigenetic clocks only provide estimates based on age-related changes, not a direct measurement of biological age.

The second myth is that supplements are a core part of improving health and longevity. Matt argues that while some supplements like vitamin D, omega-3s, and B vitamins can be beneficial when used to correct deficiencies, supplements are not essential or a core part of longevity protocols. Lifestyle factors like diet, exercise, and sleep are much more important.

The third myth is that someone can be "too old" to worry about longevity. Matt strongly disagrees with this, explaining that interventions to slow aging can be effective even when started later in life. He cites examples like the Liftmore study where older women saw benefits from strength training.

Another myth is that the FDA won't approve drugs to slow aging because aging is not recognized as a disease. Kaeberlein clarifies that this is not the case - the FDA cares about whether a drug can improve quality or quantity of life, not whether aging is classified as a disease.

The episode then tackles the myth that resveratrol is a longevity molecule. Dr. Kaeberlein states this is completely false, citing meta-analyses showing resveratrol has no net positive effect on lifespan. He is shocked that this myth persists, even among some high-profile influencers.

Kaeberlein also dispels the myth that aging research is well-funded. He points out that while 9 out of the top 10 causes of death have biological age as the greatest risk factor, aging research receives only about 0.5% of the NIH budget. He argues this level of funding is absurdly low given the importance of the biology of aging.

Another myth discussed is the idea that longevity is mostly determined by genetics. Matt states that in reality, genetics play a smaller role than environmental and lifestyle factors, likely accounting for 20-50% of longevity. He emphasizes that this means individuals have significant control over their health span and longevity trajectory through lifestyle choices.