What if longevity science worked like March Madness? Introducing the first-ever Longevity March Madness, a single-elimination tournament where 64 of the most talked-about longevity interventions go head-to-head, and the winner is decided by you. From exercise and fasting to rapamycin, supplements, and experimental therapies, a committee of five leading voices in longevity science has selected the full field of 64. Dr. Matt Kaeberlein seeds each intervention based on the strength of the scientific evidence — then the community takes over. Here's how it works: Selection Sunday: On the following Monday (the 16th), the official bracket drops. See all 64 interventions and their seedings. Fill out your bracket: Download it at the Optispan website, make your predictions, and submit before the tournament begins. Top 10 finishers win prizes. Vote: Cast your votes via submitted bracket or live polls on X and Instagram, no limit on voting. Tournament runs March 16–onward: Follow every matchup, upset, and Cinderella story on YouTube and social media.

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