In this episode, Matt describes his journey with testosterone deficiency. He noticed symptoms like low energy and libido in his 40s, but didn't make the connection until his 50s. When he finally got his testosterone tested, his primary care doctor said it was in the normal range, but the speaker later learned that total testosterone is not the most informative metric. After trying some natural supplements like boron and DHEA without success, he seriously considered testosterone therapy.

Matt was hesitant at first, concerned about potential side effects like permanent reduction in natural testosterone production, hair loss, and personality changes. He also worried about the stigma associated with testosterone therapy. After about a year of deliberation, he decided to try an oral testosterone medication called Jatenzo, but experienced side effects like water retention.

Matt then consulted Dr. White, who recommended switching to injectable testosterone instead. The expert explained that injections allow for more precise dosing and monitoring of levels. Matt has now been on injectable testosterone for about 9 months and reports significant benefits, including increased energy, libido, muscle mass, and overall wellbeing. He cautions that testosterone therapy is not right for everyone, but believes it has been a "game changer" for his health.

Matt provides guidance on the key biomarkers to monitor when on testosterone therapy, including total testosterone, free testosterone, SHBG, LH, estrogen, and DHT. He recommends aiming for physiological testosterone levels, around 700-1000 mg/dL total, and managing any increase in estrogen with a low dose of an aromatase inhibitor.

In the final part, Matt and Dr. Kevin White discuss the misconception that testosterone may accelerate aging or shorten lifespan. They argue that the data on eunuchs is inconclusive, and that restoring testosterone to normal levels in aging men is more likely to improve healthspan than hasten aging, especially when combined with a healthy lifestyle.