Forbes | The Best Biomarkers For Longevity, According To Experts
Modern medicine has been remarkably successful at extending lifespan, but further gains are likely to come from improving healthspan—the years lived in good physical and cognitive function—rather than simply adding more years. This article outlines how longevity science is shifting from treating disease late to identifying risk early through biomarkers that reflect biological aging, resilience, and long-term health trajectories.
Longevity biomarkers act like a physiological dashboard, offering early warning signs across cardiovascular, metabolic, inflammatory, hormonal, and functional domains. Experts, including Optispan CEO Matt Kaeberlein, emphasize that no single marker defines aging. Instead, patterns across lipid profiles, glucose regulation, inflammation (e.g., hs-CRP), aerobic capacity (VO₂ max), body composition, and sex hormones provide actionable insight into where interventions can meaningfully slow biological decline.
Crucially, these biomarkers are modifiable. When interpreted in clinical context, they guide targeted lifestyle changes and medical therapies—such as exercise prescriptions, nutrition strategies, sleep optimization, hormone therapy, and cardiometabolic medications—that shift aging trajectories toward greater resilience and quality of life.
Key takeaways
Lifespan gains are plateauing; healthspan optimization is the next frontier
Biomarkers quantify biological aging before disease becomes irreversible
Cardiovascular, metabolic, inflammatory, fitness, body composition, and hormonal markers matter most
Personalized interpretation and longitudinal tracking are essential
Early, data-driven intervention outperforms reactive care
Our CEO, Dr. Matt Kaeberlein, was featured in an article from Forbes! Check out the full article here!
